In the past fifty years or so, leading manufacturers have made their great efforts in introducing TPS (Toyota Production System) “zero-inventory” concept. As a result, lean manufacturing is achieved, but with excessive total warehousing operations in the production supply chain. This is because additional warehousing space are provided near the production site to hedge the risk caused by target delivery times required by zero inventory manufacturing. More recently, an increasing number of Chinese leading manufacturers are implementing Industry 4.0 or Made in China 2025. One approach is to automate warehousing operations in the factories for handling raw materials, finished products and work in progress. To some extent, automated warehouses improve operating efficiency and reduce the demand for larger land spaces. However, this may not minimize the cost of warehousing operations which are totally non-value adding in manufacturing. This research proposes a paradigm shift from zero inventory to zero warehousing in manufacturing. That is, warehousing operations are minimized to minimize the non-value adding activities and in the meanwhile minimize inventories. The talk presents the basic mechanism of zero warehouse manufacturing (ZWM), and the fundamental principles and core technologies for realizing ZWM. Digital twin technology is used to upgrade men, machines and materials into smart entities that constitute internet of things or physical internet. Mobile apps and services are aware of time and space of smart entities and they are highly synchronized to fulfill their missions. By so doing, ZWM systems avoid non-value adding operations such as shelving storage, putaway, picking and sorting, inventory audit. Ultimately, manufacturers use the lands primarily for production activities instead of warehousing operations.